He was in excellent health prior to this incident. But the wandering and "head pressing" it's called, where they just go into the corner or lean against a table leg or the wall. I to also gave my best friend Simparica as recommended by the vet. A dog fence is an important detail to consider when adopting a pet for the first time or moving your dog to a new home. As I said, the first was a week after taking it, then the 2nd and third seizure happened at day 29. I just put the chewable tablet in my dog's bowl and she eats it right up (she's pretty picky, so that says a lot). He wouldnt survive surgical attempt to go in and try to figure out what was going on. I am going to try stopping the medication for a month to see if things improve. We are currently going through this with our nine year old dachshund. Stopped meds and he has had 3 more seizures since. That is the only thing that has changed in her routine. Like many of you, I was unsure about the cause. Animal Drug Safety Communication: FDA Alerts Pet Owners and Veterinarians About Potential for Neurologic Adverse Events Associated with Certain Flea and Tick Products, How to Report Problems with Flea and Tick Products, An official website of the United States government, : Hello to everyone and I am so sorry we had to meet under these circumstances. She has NEVER done that before. I have 3 other dogs - large breeds that also took 1 dose, but no reaction. I've had to syringe water in his mouth. Before sharing sensitive information, make sure you're on a federal government site. I removed it immediately She just tested positive for Lyme's. She spent 4 nights at the University of Auburn emergency room and vet clinic. I have a vet appointment tomorrow to figure it out. My 1 year old Italian Spinone puppy has been losing hair on her back and has a big ear infection. Gave my dog Charlie Simparica yesterday now he is shaking and panting really bad. Same here! She was shaking like she was freezing. I'm totally stopping the drug, but, unfortunately, can't get in to my vet for almost a month to get a replacement. She has been the healthiest, happiest dog. the first puppy was still born looks to have died younger .my assumption when I gave lola that pill.she lost 1 puppy .the second baby is doing okay.although the vet said watch for neurological problems and GI problems. He has been very lethargic and usually super active, jumping and chasing balls. Do you have contact details that you can share with me. He had kidney failure he had seizures he had nervous system problems. Sarah thanks for your response! I just wanted them gone and for him to feel better. 13 March he is also very lethargic and sitll not eating (even his favorite treats). I'm so glad I found this forum, it confirmed my instincts that this drug is very harmful. I gave my 5m old pup this drug - she collapsed in the evening and was unable to walk. Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. I came across this site and read so much about symptoms that I now realize he has been having. Not sure what effects he will continue to have. About 11 months ago our vet recommended Simparica Trio. Hi, Im wondering whats going on with your dog now? He was lethargic & laying in his crate alot . We took him to the animal er and they checked his vitals and he was fine. Sold as 1 Month, 3 Month or 6 Month Supply for the following dog weights : 2.8-5.5 lbs, 5.5-11 lbs, 11-22 lbs, 22-44 lbs, 44-88 lbs, 88-132 lbs. Im a new pet owner and this will sound ignorant Im sure but I had NO IDEA this is how flea meds works and completely trusted my vet who knows my dogs past sensitive history and I was given the drug not even in its package so I could read anything about it but in individual pills. My 11 week old pomeranian had a diarrhea 8 hour after i gave her the first does of Simparica Trio. The neurologist I went to would not give him steroids until I did the spinal tap and MRI. . Each month he got sicker and sicker. Simparica and Simparica Trio are available by prescription only. my vet recommended this for both my yorkies. Another call to vet asking for an appt - seems like an an emergency now? Any other alternatives that are not harmful? Itching has decreased immensely. I notified my vet and Zoetis, the company that makes this drug. He has been getting groomed since he was 3 months old but we've noticed that he has been getting more anxious with time. Hi how is your pup now? Side effects of Simparica Let us now look at possible side effects when administering Simparica. Just had my 1 yr old goldendoodle to the vet because he has had 3 seizures in the last month. We talked with Zoetis (the manufacturer of Simparica) after the FDA's announcement to get some concrete numbers on the frequency of these adverse reactions. He has become more aggressive and has been growling at me sometimes when I try to move him. My dog died from it after one dose within 24 hours. My pup is scheduled to see a neurologist Monday ( today's friday) to evaluate. I just gave him heartgard and nexgard about 2 weeks with no issues. I gave my 1 year old collie cross Simparica flea and tick medication. I would, still boil chicken, carrots, potatoes for his meals. He has trouble raising his leg to urinate. I won't be letting this go and I'll be actively pursuing recourse from the manufacturer and vet in any way I can. I will never give my dog this medication again. for flea and ticks? It definitely can cross blood brain barrier and cause other neurological issues so it makes sense it could do this too, but clearly they havent done enough research to understand how. Vets at Petsmart should know better; changing vets. Im switching back to the protection he used before Simparica Trio. This excerpt is from the healthline website and in reference to humans "GABA is considered an inhibitory neurotransmitter because it blocks, or inhibits, certain brain signals and decreases activity in your nervous system. I have to turn him around and lead him away. I wouldnt have given it to her. We may also give additional medications to keep fleas, ticks, and common intestinal parasites away. Our Vet suggested Simparica Trio! Those with Diarrhea symptom, did it look like mucus in their pets stool? On 08/06 she threw up. I don't know if the lump came from it or something else. I've tried Gatorade and Ginger ale but he only drank a little. She had a beautiful coat of fur. Not long after ingesting the chewable she began to have tremors, but not full blown seizures. Then the following week 1 pill every other day . I do believe it caused her blindness. They don't really have an answer for why this happens at all, or why some dogs get better and some don't. I'm so sorry. Stressing out now. And yeah he ate today 4 chicken breast and appeared to want it even better. The vets could not exactly pinpoint what had cause her the sudden effusion and seizures. Simparica can cause ataxia, which is the official name for loss of body control. Next she developed severe tremors. Hopefully there are many other dogs that are unaffected, and just aren't written about here. Nobody knows what causes it or makes one dog recover and another not. Bentlee has been fine for 12 + hours in the house while I was stuck at work and never a drop of anything in the house. If you think that your dog has had an overdose of Simparica, contact your vet immediately to seek treatment. He is just laying in his crate . This morning (12/19/21) was a bit better, still hesitant on the steps but we didnt experience any loss of appetite and was eager to go outside (still some diarrhea though). Mine is. This was the only thing we changed, I am convinced this is what did it to her. not eating alor and wants me to rub her tummy constantly . Is there any good outcomes from this tablet? Currently, for Simparica, less than 0.01% of dogs taking this medication have experienced any neurologic side effects. Now do you get the connection? Now Im scared ive been giving him Simparica Trio and it could be the cause of his progressively worsening sickness. I don't want another animal harmed by this stuff, one animal is one to many. Vet gave her a shot which stopped it. So, I gave it to him. We all want to protect our pets from fleas, ticks and the diseases they carry, but some treatments can come with nasty side effects. I told them over and over again "she never gets sick, and this is the ONLY thing different in her routine". And both of my other labs, basically house dogs, ended up with a droopy left eye. The company that makes it said they didnt change the flavor, but I live in a high tick area, so switched to Simparica Trio. Although vet wanted to treat him for Addison's I decided to wait it out and fortunately it worked out. https://photos.app.goo.gl/GbP8UmDNBAxJ1m4g8 I feel like we are just waiting for him to pass now. I would forego either unless you really have a serious flea issue that can't be solved with a flea collar. RELATED: What You Need to Know About the Lyme Vaccine for Dogs. Simparica TRIO requires a prescription from your veterinarian. Thankfully there have been no other side effects. Some flea and tick products are, Bravecto (fluralaner) topical solution for cats and dogs, Bravecto Plus (fluralaner and moxidectin) topical solution for cats, Bravecto 1-month (fluralaner) tablets for dogs, Credelio (lotilaner) tablets for dogs and cats, Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs, Revolution Plus (selamectin and sarolaner) topical solutionfor cats. My Jack Russell Terrier has taken Simparica Trio for several months. She has been treated by this clinic since birth. Im just hoping my sweet girl is going to be ok. My English Springer Spaniel(Sadie) received her first dose of Simparica Trio at 12 weeks old, with no noticeable side effects. The vet wont acknowledge it was Simparica although Dolly had no problems with seizures before. My 15 yr old doodle wasnt given bravecto because of reviews. Hi Laura, How is you pup doing one after getting off simparica? Other adverse reactions like lethargy, anorexia, itching, and increased thirst are possible but not very likely. Does anyone know of anything we can give her to help get this out of her system? I just gave Bentlee my Akita Simparica Trio on the 9th. The only thing the vet can say, was a sore neck. Another difference is flavor. Hi there, my dog has been taking simparica trio for two months. That sh-t should be banned. For me, Simparica Trio has made parasite control effective and easyI just give her one chewable tablet each month. Im wondering if after it is out of his system or have I now poisoned my baby where he might have a seizure disorder for the rest of his life. Doesn't anyone here wonder why?, if this is sooo safe to use with mammals, isn't there a human version also available? I cant believe how long this thread is. I just found these comments and I am feeling terrible. Hi, I was just wondering how long you continued on with the steroids with your puppy. We are already close to $2000 in Vet bills not counting the poison we bought her. The most common Simparica Trio for dogs side effects are; Lethargy Vomiting Diarrhea Loss of appetite Polydipsia Polyuria Hyperactivity Hyperactivity, polydipsia, and polyuria happened in very rare cases. Side effects The contra indication is important to know before you utilize the simparica. This is apparently not true and that's why the article never goes on to explain exactly why it only works on GABA receptors in fleas and ticks yet not affect the GABA receptors in your dog. The .gov means its official.Federal government websites often end in .gov or .mil. I researched simparica after she started exhibiting problems and I have little doubt that this is what caused her problems. Is the added expense worth the trouble to insure your beloved pet? The vet said the simparica didn't cause the disease but it could have been the link that pushed him into the Crisis. 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